副腎内分泌

研究グループの名称

副腎内分泌グループ

研究室主任および研究室メンバー

栗原勲

専門

総合内科専門医、指導医　内分泌代謝内科専門医、指導医腎臓専門医　高血圧専門医

1997年3月 慶應義塾大学医学部卒業
1997年4月 慶應義塾大学病院内科（研修医）
慶應義塾大学大学院医学研究科博士課程（内科系内科学）入学
2003年11月 米国Baylor医科大学分子細胞生物学（研究留学）
2007年4月 足利赤十字病院内科
2008年4月 慶應義塾大学医学部特任助教
2009年6月 慶應義塾大学医学部助教（有期）
2011年10月 慶應義塾大学医学部講師（有期）
2013年10月 慶應義塾大学医学部専任講師

研究室メンバー：（学内）

  • 小林佐紀子（H10年）
  • 横田健一（H13年）
  • 乃村元子（H13年）
  • 武田彩乃（H14年、保健管理センター在籍）
  • 三石木綿子（H15年、予防医療センター在籍）
  • 高畑尚（H22年）
  • 大嶋洋佑（H23年）
  • 南悠季子（H24年）
  • 齋藤洸平（H25年）
  • 上妻嵩英（H26年）
  • 鳥光拓人（H26年）
  • 川合未来（H27年）
  • 押田卓磨（H27年）

研究室メンバー：（学外）

  • 柴田洋孝（S63年、大分大学医学部内分泌代謝・膠原病・腎臓内科学講座・教授）
  • 鈴木利彦（H5年、東京ベイ浦安・市川医療センター）
  • 安藤孝（H6年、東京女子医大内科学・講師）
  • 冠城徳子（H11年、渋谷ステーションクリニック）
  • 林毅（H15年、東京慈恵会医科大学葛飾医療センター）
  • 本杉裕一郎（H16年、すぎ内科・糖尿病クリニック）
  • 城理絵（H17年、けいゆう病院）
  • 大山貴子（H18年、大山整形外科）
  • 中村俊文(H20年、コルドリエ研究センター（フランス））
  • 盛崎瑞葉（H21年、伊藤病院）

研究のメインテーマ

  • 原発性アルドステロン症の診療ガイドラインに直結するエビデンスの創出
  • ミネラルコルチコイド受容体（MR）の新規活性化機構の解明
  • 腸管MRの新規機能の解明

研究概要

原発性アルドステロン症は高血圧症の数％を占める二次性高血圧であり、本態性高血圧に比べて心臓や血管、腎臓など様々な臓器に及ぼす悪影響が懸念されることから、的確な診断と治療が求められる。当科は全国でも屈指の原発性アルドステロン症患者受け入れ数を誇り、本疾患の正確かつ効率的な診断や合併症・予後調査に関わる臨床研究を行っている。近年では、segmental AVS（超選択的副腎静脈サンプリング）を用いた副腎部分切除術（副腎皮質温存手術）適応の判断や低侵襲ラジオ波アブレーション治療の治験参加など、最先端の診療を心がけて情報発信している。また基礎研究においては、アルドステロン受容体（ミネラルコルチコイド受容体：MR）に着目し、MRを介した高血圧（MR関連高血圧）発症の分子メカニズムや、腸管でのアルドステロン作用の解析を進めてきた。その結果、高血圧発症における新規MR転写共役因子の関与や、腸管MRによる新規血圧調節機構を明らかにした。現在このような視点に立ちミネラルコルチコイド高血圧の病態解明についてさらなる研究を進めている。

代表的論文の紹介

Intestinal Mineralocorticoid Receptor Contributes to ENaC-Mediated Intestinal Sodium Absorption and Blood Pressure Regulation.
Toshifumi Nakamura et al.
J Am Heart Assoc. 2018 Jun 21;7(13). pii: e008259.

従来の医学書では、アルドステロンによる血圧調節作用は、遠位尿細管～集合管に発現する腎臓のMRが主役と記載されている。本論文では、腸管上皮特異的MR欠損マウスの表現型解析を通して、血圧調節作用において腸管MRが腎MRと同等の寄与であることを明らかにした。このマウスを低塩分食で飼育すると、Na欠乏に陥り、著明な体重減少と血圧低下を認めることから、血圧のホメオスタシスにおいて、腸管MRが極めて重要な意義を持つことが明らかにされた（右図）。

業績

  1. Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort.
    Morisaki M, Kurihara I, Itoh H, Naruse M, Takeda Y, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Sone M, Tsuiki M, Shibata H, Kawashima J, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Suzuki T; JPAS Study Group.
    J Endocr Soc. 2019 Aug 22;3(11):2012-2022.

  2. ARMC5 Alterations in Primary Macronodular Adrenal Hyperplasia (PMAH) and the Clinical State of Variant Carriers.
    Kyo C, Usui T, Kosugi R, Torii M, Yonemoto T, Ogawa T, Kotani M, Tamura N, Yamamoto Y, Katabami T, Kurihara I, Saito K, Kanamoto N, Fukuoka H, Wada N, Murabe H, Inoue T.
    J Endocr Soc. 2019 Jul 23;3(10):1837-1846.

  3. Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan.
    Fujii Y, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Yamamto K, Ogo A, Yanase T, Okamura S, Miyauchi S, Fujita M, Suzuki T, Umakoshi H, Ogasawara T, Tsuiki M, Naruse M; JPAS Study Group.
    J Hum Hypertens. 2020 Jan;34(1):34-42.

  4. Association Between Acute Fall in Estimated Glomerular Filtration Rate After Treatment for Primary Aldosteronism and Long-Term Decline in Renal Function.
    Kobayashi H, Abe M, Nakamura Y, Takahashi K, Fujita M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Wada N, Ichijo T, Katabami T, Ogawa Y, Kawashima J, Yoshimoto T, Sone M, Inagaki N, Watanabe M, Kamemura K, Matsuda Y, Izawa S, Tanabe M, Tanabe A, Suzuki T, Naruse M; JPAS/JRAS Study Group.
    Hypertension. 2019 Sep;74(3):630-638.

  5. Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.
    Kawashima A, Sone M, Inagaki N, Takeda Y, Itoh H, Kurihara I, Umakoshi H, Ichijo T, Katabami T, Wada N, Ogawa Y, Kawashima J, Fujita M, Miyauchi S, Okamura S, Fukuoka T, Yanase T, Izawa S, Yoshikawa Y, Hashimoto S, Yamada M, Kai T, Suzuki T, Naruse M.
    Eur J Endocrinol. 2019 Jul 1. [Epub ahead of print]

  6. Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.
    Wada N, Shibayama Y, Yoneda T, Katabami T, Kurihara I, Tsuiki M, Ichijo T, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Tamura K, Kamemura K, Otsuki M, Okamura S, Naruse M; JPAS/JRAS Study Group.
    J Endocr Soc. 2019 May 16;3(7):1393-1402.

  7. Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients With Primary Aldosteronism.
    Akasaka H, Yamamoto K, Rakugi H, Nagasawa M, Nakamaru R, Ichijo T, Takeda Y, Kurihara I, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Kamemura K, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Watanabe M, Tamura K, Okamura S, Miyauchi S, Izawa S, Chiba Y, Tanabe A, Naruse M; Japan Primary Aldosteronism Study Group *.
    Hypertension. 2019 Aug;74(2):368-374.

  8. Clinical and biochemical outcomes after adrenalectomy and medical treatment in patients with unilateral primary aldosteronism.
    Katabami T, Fukuda H, Tsukiyama H, Tanaka Y, Takeda Y, Kurihara I, Ito H, Tsuiki M, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Yanase T, Suzuki T, Naruse M; JPAS/JRAS Study Group.

  9. Latent Autonomous Cortisol Secretion From Apparently Nonfunctioning Adrenal Tumor in Nonlateralized Hyperaldosteronism.
    Ohno Y, Sone M, Inagaki N, Takeda Y, Kurihara I, Tsuiki M, Ichijo T, Wada N, Katabami T, Ogawa Y, Okamura S, Fukuoka T, Kai T, Izawa S, Yoshikawa Y, Hashimoto S, Yamada M, Chiba Y, Naruse M; JPAS/JRAS Study Group.
    J Clin Endocrinol Metab. 2019 Oct 1;104(10):4382-4389.

  10. Influence of antihypertensive drugs in the subtype diagnosis of primary aldosteronism by adrenal venous sampling.
    Nagasawa M, Yamamoto K, Rakugi H, Takeda M, Akasaka H, Umakoshi H, Tsuiki M, Takeda Y, Kurihara I, Itoh H, Ichijo T, Katabami T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Ogo A, Okamura S, Miyauchi S, Yanase T, Suzuki T, Kawamura T, Naruse M; JPAS Study Group.
    J Hypertens. 2019 Jul;37(7):1493-1499.

  11. High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.
    Akehi Y, Yanase T, Motonaga R, Umakoshi H, Tsuiki M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M; Japan Primary Aldosteronism Study Group.
    Diabetes Care. 2019 May;42(5):938-945.

  12. Usefulness of hemoglobin A1c and glycated albumin measurements for insulinoma screening: an observational case-control study.
    Torimoto K, Okada Y, Tanaka Y, Matsuoka A, Hirota Y, Ogawa W, Saisho Y, Kurihara I, Itoh H, Inada S, Koga M.
    BMC Cancer. 2019 Feb 26;19(1):174.

  13. Impact of adrenocorticotropic hormone stimulation during adrenal venous sampling on outcomes of primary aldosteronism.
    Takeda Y, Umakoshi H, Takeda Y, Yoneda T, Kurihara I, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Yanase T, Suzuki T, Naruse M; JPAS Study Group.
    J Hypertens. 2019 May;37(5):1077-1082.

  14. Obesity as a Key Factor Underlying Idiopathic Hyperaldosteronism.
    Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, Kurihara I, Umakoshi H, Ichijo T, Katabami T, Wada N, Ogawa Y, Yoshimoto T, Kawashima J, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Miyauchi S, Kamemura K, Fukuoka T, Yamamoto K, Otsuki M, Suzuki T, Naruse M; JPAS Study Group.
    J Clin Endocrinol Metab. 2018 Dec 1;103(12):4456-4464.

  15. Pulmonary nocardiosis mimicking small cell lung cancer in ectopic ACTH syndrome associated with transformation of olfactory neuroblastoma: a case report.
    Kobayashi K, Asakura T, Ishii M, Ueda S, Irie H, Ozawa H, Saitoh K, Kurihara I, Itoh H, Betsuyaku T.
    BMC Pulm Med. 2018 Aug 22;18(1):142.

  16. Organ memory: a key principle for understanding the pathophysiology of hypertension and other non-communicable diseases.
    Itoh H, Kurihara I, Miyashita K.
    Hypertens Res. 2018 Oct;41(10):771-779.

  17. Clinical Characteristics and Postoperative Outcomes of Primary Aldosteronism in the Elderly.
    Takeda M, Yamamoto K, Akasaka H, Rakugi H, Naruse M, Takeda Y, Kurihara I, Itoh H, Umakoshi H, Tsuiki M, Ichijo T, Katabami T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Ogo A, Okamura S, Miyauchi S, Yanase T, Suzuki T, Kawamura T; JPAS Study Group.
    J Clin Endocrinol Metab. 2018 Oct 1;103(10):3620-3629.

  18. Correlation Between Lateralization Index of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism.
    Umakoshi H, Tsuiki M, Yokomoto-Umakoshi M, Takeda Y, Takashi Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yanase T, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M.
    J Endocr Soc. 2018 May 24;2(8):893-902.

  19. Development and validation of subtype prediction scores for the workup of primary aldosteronism.
    Kobayashi H, Abe M, Soma M, Takeda Y, Kurihara I, Itoh H, Umakoshi H, Tsuiki M, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Shibata H, Kamemura K, Yanase T, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Nanba K, Tanabe A, Suzuki T, Naruse M; JPAS Study Group.
    J Hypertens. 2018 Nov;36(11):2269-2276.

  20. Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel-Mediated Intestinal Sodium Absorption and Blood Pressure Regulation.
    Nakamura T, Kurihara I, Kobayashi S, Yokota K, Murai-Takeda A, Mitsuishi Y, Morisaki M, Kohata N, Oshima Y, Minami Y, Shibata H, Itoh H.
    J Am Heart Assoc. 2018 Jun 21;7(13). pii: e008259.

  21. The Occurrence of Apparent Bilateral Aldosterone Suppression in Adrenal Vein Sampling for Primary Aldosteronism.
    Shibayama Y, Wada N, Naruse M, Kurihara I, Ito H, Yoneda T, Takeda Y, Umakoshi H, Tsuiki M, Ichijo T, Fukuda H, Katabami T, Yoshimoto T, Ogawa Y, Kawashima J, Ohno Y, Sone M, Fujita M, Takahashi K, Shibata H, Kamemura K, Fujii Y, Yamamoto K, Suzuki T.
    J Endocr Soc. 2018 Mar 22;2(5):398-407.

  22. Bilateral Adrenal Hyperplasia Due to Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma on FDG PET and 111In-Pentetreotide Scintigraphy.
    Matsusaka Y, Nakahara T, Kurihara I, Iwabuchi Y, Jinzaki M.
    Clin Nucl Med. 2018 Jun;43(6):452-453.

  23. Two-stage resection of a bilateral pheochromocytoma and pancreatic neuroendocrine tumor in a patient with von Hippel-Lindau disease: A case report.
    Endo Y, Kitago M, Miyajima A, Kurihara I, Kameyama K, Shinoda M, Yagi H, Abe Y, Hibi T, Takagi C, Nakano Y, Koizumi W, Itano O, Kitagawa Y.
    Int J Surg Case Rep. 2018;44:139-142.

  24. Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism.
    Umakoshi H, Ogasawara T, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Yanase T, Okamura S, Miyauchi S, Suzuki T, Tsuiki M, Naruse M.
    Clin Endocrinol (Oxf). 2018 May;88(5):645-651.

  25. Epidermal growth factor receptor/extracellular signal-regulated kinase pathway enhances mineralocorticoid receptor transcriptional activity through protein stabilization.
    Mitsuishi Y, Shibata H, Kurihara I, Kobayashi S, Yokota K, Murai-Takeda A, Hayashi T, Jo R, Nakamura T, Morisaki M, Itoh H.
    Mol Cell Endocrinol. 2018 Sep 15;473:89-99.

  26. Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan.
    Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, Kurihara I, Itoh H, Umakoshi H, Tsuiki M, Ichijo T, Katabami T, Tanaka Y, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yoneda T, Hashimoto S, Yanase T, Suzuki T, Kawamura T, Tabara Y, Matsuda F, Naruse M; Nagahama Study; JPAS Study Group.
    Hypertension. 2018 Mar;71(3):530-537.

  27. Significance of Computed Tomography and Serum Potassium in Predicting Subtype Diagnosis of Primary Aldosteronism.
    Umakoshi H, Tsuiki M, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Yanase T, Suzuki T, Naruse M; JPAS Study Group.
    J Clin Endocrinol Metab. 2018 Mar 1;103(3):900-908.

  28. High Glucose Stimulates Mineralocorticoid Receptor Transcriptional Activity Through the Protein Kinase C β Signaling.
    Hayashi T, Shibata H, Kurihara I, Yokota K, Mitsuishi Y, Ohashi K, Murai-Takeda A, Jo R, Ohyama T, Sakamoto M, Tojo K, Tajima N, Utsunomiya K, Itoh H.
    Int Heart J. 2017 Oct 21;58(5):794-802.

  29. Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.
    Kurosawa H, Saisho Y, Fukunaga K, Haraguchi M, Yamasawa W, Kurihara I, Betsuyaku T, Itoh H.
    Endocr J. 2018 Jan 30;65(1):121-127.

  30. Clinical significance of ‘cardiometabolic memory’: a systematic review of randomized controlled trials.
    Itoh H, Kurihara I, Miyashita K, Tanaka M.
    Hypertens Res. 2017 Jun;40(6):526-534.

  32. A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH).
    Kobayashi S, Yoshimura Noh J, Shimizu T, Sato T, Kurihara I, Sugino K, Itoh
    H, Ito K.
    Endocr J. 2017 Feb 27;64(2):207-212.

  33. Calibration and evaluation of routine methods by serum certified reference material for aldosterone measurement in blood.
    Nishikawa T, Omura M, Kawaguchi M, Takatsu A, Satoh F, Ito S, Kurihara I, Itoh H, Yanase T, Shibata H, Oki Y, Naruse M, Sakurai K, Sasamoto H, Kuwa K.
    Endocr J. 2016 Dec 30;63(12):1065-1080.

  34. Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism.
    Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K.
    J Clin Endocrinol Metab. 2016 Jan;101(1):6-9

  35. Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1.
    Suda N, Shibata H, Kurihara I, Ikeda Y, Kobayashi S, Yokota K, Murai-Takeda A, Nakagawa K, Oya M, Murai M, Rainey WE, Saruta T, Itoh H.
    Endocrinology. 2011 Jun;152(6):2266-77

  36. Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.
    Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang CY, McDonnell DP.
    Mol Endocrinol. 2010 Dec;24(12):2292-302.

  37. NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor.
    Murai-Takeda A, Shibata H, Kurihara I, Kobayashi S, Yokota K, Suda N, Mitsuishi Y, Jo R, Kitagawa H, Kato S, Saruta T, Itoh H.
    J Biol Chem. 2010 Mar 12;285(11):8084-93

  38. Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization.
    Lee DK, Kurihara I, Jeong JW, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY.
    Mol Endocrinol. 2010 May;24(5):930-40.

  39. COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity.
    Kurihara I, Lee DK, Petit FG, Jeong J, Lee K, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY.　PLoS Genet. 2007

  40. Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental
    deficiency.
    Petit FG, Jamin SP, Kurihara I, Behringer RR, DeMayo FJ, Tsai MJ, Tsai SY.
    Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6293-8.

  41. Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction.
    Takamoto N, Kurihara I, Lee K, Demayo FJ, Tsai MJ, Tsai SY.
    Mol Endocrinol. 2005 Sep;19(9):2299-308.

  42. Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9.
    Yokota K, Shibata H, Kurihara I, Kobayashi S, Suda N, Murai-Takeda A, Saito I, Kitagawa H, Kato S, Saruta T, Itoh H.
    J Biol Chem. 2007 Jan 19;282(3):1998-2010